PICH: A DNA Translocase Specially Adapted for Processing Anaphase Bridge DNA
نویسندگان
چکیده
منابع مشابه
PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution
Centromeres nucleate the formation of kinetochores and are vital for chromosome segregation during mitosis. The SNF2 family helicase PICH (Plk1-interacting checkpoint helicase) and the BLM (the Bloom's syndrome protein) helicase decorate ultrafine histone-negative DNA threads that link the segregating sister centromeres during anaphase. The functions of PICH and BLM at these threads are not und...
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PICH is a SNF2 family DNA translocase that binds to ultra-fine DNA bridges (UFBs) in mitosis. Numerous roles for PICH have been proposed from protein depletion experiments, but a consensus has failed to emerge. Here, we report that deletion of PICH in avian cells causes chromosome structural abnormalities, and hypersensitivity to an inhibitor of Topoisomerase II (Topo II), ICRF-193. ICRF-193-tr...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2013
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2013.07.016